Have you ever played Diablo II? Titan Quest Anniversary Edition is basically that with a more varied skill system, a few quality of life improvements (base health/mana regen, infinite portals, keep equipment on death, no item durability, easy respec), and no random maps.
The maps are quite linear, the sidequests amount to killing/finding things, and the dialog and storyline are both very simple. If you don’t enjoy wandering around viciously murdering hordes of enemies while constantly picking up shiny new equipment there won’t really be any reason to play this game. On the plus side you pretty much never have to backtrack through a previously cleared location (there are 2-3 exceptions in Act IV, added by the Immortal Throne expansion).
My first playthrough was with a Diviner (Mind/Spirit) who focused mainly on ranged attacks, Psionic Immolation (which killed nearly every non-boss in one hit once maxed out), and the Lich summon. At the end of Normal they were at level 40 and ready to start maxing out Lich and Temporal Rift (which turns out is even nastier than PI) in Epic.
Despite not being optimized in the slightest and not doing any real grinding, for the most part I didn’t have any trouble getting through to the end. Hades’ third form did kill me something like 6 times though because Immolation kept missing his floating body and his life drain wave did tons of damage. However, before going into Epic with this character I think I’m going to run through Normal/Epic with a lightning-spam Oracle (Spirit/Storm, which apparently isn’t very gear dependent) so that I can find better Diviner-focused equipment, as I suspect it won’t do too well in Epic just using whatever.