Popuko, short and quick to anger, and Pipimi, tall and laid back, are two halves of the whole that is Pop Team Epic. Two rude and crude schoolgirls who often find themselves in all sorts of bizarre and surreal situations.
A gag comedy focused on abstract/random and meta 4th-wall breaking humor. Be aware that most episodes repeat themselves halfway through with different voice actors, and that while based on a manga strip much of the content is Anime-original.
More Information:
Amazon
aniDB (1, 2)
Crunchyroll
HIDIVE
Wikipedia